ERO1α inhibitor I29

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Chemical Structure : ERO1α inhibitor I29

Catalog No.: PC-28593Not For Human Use, Lab Use Only.

ERO1α inhibitor I29 is a specific small molecule inhibitor of Endoplasmic reticulum oxidoreductin 1 alpha (ERO1A, ERO1α) with IC50 of 2.6 uM, inhibits ERO1-driven triple-negative breast cancer and SEPN1-related myopathy, phenocopies ERO1α genetic deletion and enhances efficacy of anti-PD-1 therapy.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	400.33
Formula	C21H12F4N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-fluorophenyl)-4-((5-phenylfuran-2-yl)methylene)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one

References

1. Varone E, et al. Cell Death Dis. 16 (2025) 105, 10.1038/s41419-025-07426-1.

2. Michele Retini, et al. Pharmacol Res. 2025 Dec:222:108037.

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