ERP1.28a | CDC-7 inhibitor | Probechem Biochemicals

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Chemical Structure : ERP1.28a

ERP1.28a (CDC-7 inhibitor)

Catalog No.: PC-38769Not For Human Use, Lab Use Only.

ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.
ERP1.28a prevents cytosolic accumulation of TDP-43.
ERP1.28a treatment leads to recovering the nuclear function of TDP-43-inducing CDK6 repression in FTLD-TDP lymphoblasts.

Physicochemical Properties

M.Wt	276.742
Formula	C12H9ClN4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((3-chlorobenzyl)thio)-9H-purine

References

1. Vaca G, et al. J Neurochem. 2021 Feb;156(3):379-390.

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