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Chemical Structure : ERP1.28a
Catalog No.: PC-38769Not For Human Use, Lab Use Only.
ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.
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ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.
ERP1.28a prevents cytosolic accumulation of TDP-43.
ERP1.28a treatment leads to recovering the nuclear function of TDP-43-inducing CDK6 repression in FTLD-TDP lymphoblasts.
| M.Wt | 276.742 | |
| Formula | C12H9ClN4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vaca G, et al. J Neurochem. 2021 Feb;156(3):379-390.
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