Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ERP1.28a
Catalog No.: PC-38769Not For Human Use, Lab Use Only.
ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS.
ERP1.28a prevents cytosolic accumulation of TDP-43.
ERP1.28a treatment leads to recovering the nuclear function of TDP-43-inducing CDK6 repression in FTLD-TDP lymphoblasts.
| M.Wt | 276.742 | |
| Formula | C12H9ClN4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Vaca G, et al. J Neurochem. 2021 Feb;156(3):379-390.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
