Chemical Structure : ERW1041E
CAS No.:
918440-87-6
ERW1041E
(ERW 1041E)
Catalog No.: PC-21656Not For Human Use, Lab Use Only.
ERW1041E is a specific, irreversible small molecule transglutaminase 2 (TGase 2; TG2) inhibitor with Ki of 11 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ERW1041E is a specific, irreversible small molecule transglutaminase 2 (TGase 2; TG2) inhibitor with Ki of 11 uM.
ERW1041E attenuated left ventricular diastolic dysfunction and reduced cardiomyocyte hypertrophy and interstitial fibrosis in the pressure-overloaded heart, without affecting chamber dimensions and ejection fraction.
ERW1041E significantly reduced hypoxia-induced cross-linking activity and synthesis of collagen 1 and α-smooth muscle actin in both the in vivo and in vitro studies.
Physicochemical Properties
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M.Wt
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461.32
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Formula
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C20H21BrN4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-quinolin-3-ylmethyl 2-((((S)-3-bromo-4,5-dihydroisoxazol-5- yl)methyl)carbamoyl)pyrrolidine-1-carboxylate
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References
1. Dafik L, et al. PLoS One. 2012;7(2):e30642.
2. Penumatsa KC, et al. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L752-L762.
3. R Edward Watts, et al. J Med Chem. 2006 Dec 14;49(25):7493-501.
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