Chemical Structure : ERW1041E
CAS No.:
918440-87-6
ERW1041E
(ERW 1041E)
Catalog No.: PC-21656Not For Human Use, Lab Use Only.
ERW1041E is a specific, irreversible small molecule transglutaminase 2 (TGase 2; TG2) inhibitor with Ki of 11 uM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ERW1041E is a specific, irreversible small molecule transglutaminase 2 (TGase 2; TG2) inhibitor with Ki of 11 uM.
ERW1041E attenuated left ventricular diastolic dysfunction and reduced cardiomyocyte hypertrophy and interstitial fibrosis in the pressure-overloaded heart, without affecting chamber dimensions and ejection fraction.
ERW1041E significantly reduced hypoxia-induced cross-linking activity and synthesis of collagen 1 and α-smooth muscle actin in both the in vivo and in vitro studies.
Physicochemical Properties
|
M.Wt
|
461.32
|
|
Formula
|
C20H21BrN4O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-quinolin-3-ylmethyl 2-((((S)-3-bromo-4,5-dihydroisoxazol-5- yl)methyl)carbamoyl)pyrrolidine-1-carboxylate
|
References
1. Dafik L, et al. PLoS One. 2012;7(2):e30642.
2. Penumatsa KC, et al. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L752-L762.
3. R Edward Watts, et al. J Med Chem. 2006 Dec 14;49(25):7493-501.
Contact Us
sales@probechem.com
