ESG-1-60

Chemical Structure : ESG-1-60

Catalog No.: PC-24331Not For Human Use, Lab Use Only.

ESG-1-60 is a potent, selective partial agonist of dopamine D3 receptor (D3R) with Ki of 0.14 nM, EC50 of 3.43 nM (Go activation) and 0.2 nM (β-arrestin2 recruitment), show ~20-fold binding selectivity for D3 over D2 receptors.

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Biological Activity

Physicochemical Properties

M.Wt	442.43
Formula	C22H33Cl2N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Propanamide, N-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-3-methoxy-

References

1. Soler-Cedeño O, et al. Br J Pharmacol. 2025 Mar 27. doi: 10.1111/bph.70021.

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ESG-1-60

Biological Activity

Physicochemical Properties

References

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