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Chemical Structure : ESI-09
CAS No.: 263707-16-0
Catalog No.: PC-45049Not For Human Use, Lab Use Only.
ESI-09 is a specific, noncyclic nucleotide EPAC antagonist (IC50=9 uM) with no effect towards PKA.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 250 mg | Get quote |
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ESI-09 is a specific, noncyclic nucleotide EPAC antagonist (IC50=9 uM) with no effect towards PKA.
ESI-09 specifically blocks intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells.
ESI-09 inhibits cAMP-mediated EPAC2 GEF activity and cAMP-mediated EPAC1 GEF activity with IC50 of 1.4 and 3.2 uM, respectively.
ESI-09 inhibits pancreatic cancer cell migration and invasion.
| M.Wt | 330.7689 | |
| Formula | C16H15ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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| Chemical Name/SMILES |
3-Isoxazolepropanenitrile, α-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo- |
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1. Almahariq M, et al. Mol Pharmacol. 2013 Jan;83(1):122-8.
2. Singhmar P, et al. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41.
3. Wang H, et al. Sci Rep. 2016 Nov 10;6:36552.
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