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Chemical Structure : ETC-6152
Catalog No.: PC-21370Not For Human Use, Lab Use Only.
ETC-6152 is a potent, specific and covalent E2 ubiquitin ligase UBE2T inhibitor with IC50 of 0.22 uM, targets Cys86 of UBE2T and shows selectivity on UBE2T over UBE2K.
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ETC-6152 is a potent, specific and covalent E2 ubiquitin ligase UBE2T inhibitor with IC50 of 0.22 uM, targets Cys86 of UBE2T and shows selectivity on UBE2T over UBE2K.
ETC-6152 inhibited the HTRF signal in E1-E2T assay with IC50 of 0.16 uM.
ETC-6152 shows weakly inhibiton against UBE2K (IC50=49.4 uM).
ETC-6152 targets UBE2T on accepting the ubiquitin transfer from UBE1 in the ubiquitylation cascade.
| M.Wt | 364.80 | |
| Formula | C15H13ClN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Anantharajan J, et al. Biochem Biophys Res Commun. 2023 Nov 11;689:149238.
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