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EXEL-8232

Chemical Structure : EXEL-8232

CAS No.:

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EXEL-8232 (EXEL 8232;EXEL8232)

Catalog No.: PC-61277Not For Human Use, Lab Use Only.

A potent and selective, orally bioavailable JAK2 inhibitor with IC50 of 2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent and selective, orally bioavailable JAK2 inhibitor with IC50 of 2 nM; displays >10-fold selectivity over JAK1, JAK3 and Tyk2, and 56 other tyrosine and serinethreonine kinases; inhibits proliferation of SET-2 and UKE-1 cells with IC50 of 177 and 146 nM respectively; effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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