EYA2-IN-1

Chemical Structure : EYA2-IN-1

Catalog No.: PC-27140Not For Human Use, Lab Use Only.

EYA2-IN-1 is a specific, small molecule allosteric EYA2 inhibitor with IC50 of 0.36 uM, inhibits cell growth of medulloblastoma cell line D458 with GI50 of 1.9 uM.

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Biological Activity

EYA2-IN-1 is a specific, small molecule allosteric EYA2 inhibitor with IC50 of 0.36 uM, inhibits cell growth of medulloblastoma cell line D458 with GI50 of 1.9 uM.
EYA2-IN-1 shows weak to no inhibition against EYA3 and EYA4, PTP1B and Scp1.

Physicochemical Properties

M.Wt	357.42
Formula	C17H12FN3OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-fluoro-N'-((5-(pyridin-2-ylthio)thiophen-2-yl)methylene)benzohydrazide

References

1. Lukas Gardner, et al. ChemMedChem. 2024 Sep 16;19(18):e202400179.

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EYA2-IN-1

Biological Activity

Physicochemical Properties

References

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