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EYA2 degrader EC21

Chemical Structure : EYA2 degrader EC21

CAS No.:

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EYA2 degrader EC21

Catalog No.: PC-27139Not For Human Use, Lab Use Only.

EYA2 degrader EC21 is a bifunctional small molecule EYA2 degrader via CDK6 recruitment, enhances the interaction between CDK6 and EYA2, thereby promoting EYA2 degradation, disrupts DNA damage repair pathways and significantly suppresses breast cancer cell proliferation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EYA2 degrader EC21 is a bifunctional small molecule EYA2 degrader via CDK6 recruitment, enhances the interaction between CDK6 and EYA2, thereby promoting EYA2 degradation, disrupts DNA damage repair pathways and significantly suppresses breast cancer cell proliferation.

Physicochemical Properties

M.Wt 1013.12
Formula C53H60N10O11
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-(14-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-14-oxo-3,6,9,12-tetraoxatetradecyl)-5-((2-(3-phenoxybenzoyl)hydrazineylidene)methyl)furan-2-carboxamide

References

1. Zhang Y, et al. Eur J Med Chem. 2026 Jun 18;317:119065.

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