Catalog No.: PC-27560Not For Human Use, Lab Use Only.
EZ-482 is a small molecule ligand of Apolipoprotein E (ApoE), binds to the C-terminal domains of both ApoE3 and ApoE4 with KD of approximately 8 μM, blocks heparin binding to the N-terminal domain.
EZ-482 is a small molecule ligand of Apolipoprotein E (ApoE), binds to the C-terminal domains of both ApoE3 and ApoE4 with KD of approximately 8 μM, blocks heparin binding to the N-terminal domain. EZ-482 overcomes ICB resistance induced by M2-exo administration. EZ-482 reverses ICB resistance induced by M2-exo in preclinical tumor models. EZ-482 effectively prevented APPNEV-induced synaptic formation impairment, APPNEV-mediated downregulation of synaptic proteins, and the APPNEV-induced decrease in synaptic maturity. EZ-482 may affect apoE binding both the LRP-1 and LDL receptors.
