Ecteinascidin 770 |CAS:114899-80-8 Probechem Biochemicals

Chemical Structure : Ecteinascidin 770

CAS No.: 114899-80-8

Ecteinascidin 770 (Ecteinascidine 770;Et 770;Et-770;Et770)

Catalog No.: PC-42331Not For Human Use, Lab Use Only.

A tetrahydroisoquinoline alkaloid with potent anticaner activities.

Packing	Price	Stock
5 mg	$280	In stock
10 mg	$400	In stock
50 mg	$1200	In stock
100 mg	$1680	In stock

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Biological Activity

A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively; sensitizes H23 the cells by activating the p53 protein, down-regulates MCL1 and up-regulates BAX proteins, with no effect on Bcl-2; enhances anoikis response of human lung cancer H23 and H460 cells.

Physicochemical Properties

M.Wt	770.84728
Formula	C40H42N4O10S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR,

References

1. Saktrakulkla P, et al. Bioorg Med Chem. 2011 Aug 1;19(15):4421-36.

2. Powan P, et al. Anticancer Res. 2013 Feb;33(2):505-12.

3. Puthongking P, et al. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1010-6.

Ecteinascidin 770 (Ecteinascidine 770;Et 770;Et-770;Et770)

Biological Activity

Physicochemical Properties

References

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