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Chemical Structure : Ecteinascidin 770
CAS No.: 114899-80-8
Catalog No.: PC-42331Not For Human Use, Lab Use Only.
A tetrahydroisoquinoline alkaloid with potent anticaner activities.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively; sensitizes H23 the cells by activating the p53 protein, down-regulates MCL1 and up-regulates BAX proteins, with no effect on Bcl-2; enhances anoikis response of human lung cancer H23 and H460 cells.
| M.Wt | 770.84728 | |
| Formula | C40H42N4O10S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR, |
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1. Saktrakulkla P, et al. Bioorg Med Chem. 2011 Aug 1;19(15):4421-36.
2. Powan P, et al. Anticancer Res. 2013 Feb;33(2):505-12.
3. Puthongking P, et al. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1010-6.
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