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Elobixibat hydrate

Chemical Structure : Elobixibat hydrate

CAS No.: 1633824-78-8

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Elobixibat hydrate (A3309, AZD7806)

Catalog No.: PC-23610Not For Human Use, Lab Use Only.

Elobixibat hydrate (A3309, AZD7806, AJG-533) is an orally available, potent and selective apical sodium-dependent bile acid transporter (ASBT, ileal bile acid transporter (IBAT) and SLC10A2) inhibitor with IC50 of 0.53 nM, 0.13 nM, and 5.8 nM for human, mouse, and canine IBAT respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Elobixibat hydrate (A3309, AZD7806, AJG-533) is an orally available, potent and selective apical sodium-dependent bile acid transporter (ASBT, ileal bile acid transporter (IBAT) and SLC10A2) inhibitor with IC50 of 0.53 nM, 0.13 nM, and 5.8 nM for human, mouse, and canine IBAT respectively.

Physicochemical Properties

M.Wt 713.91
Formula C36H47N3O8S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(2-(2-((3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-8-yl)oxy)acetamido)-2-phenylacetyl)glycine hydrate

References

1. Chey WD, et al. Gastroenterol. 2014 May;109(5):782.

2. Wong BS, et al. Expert Opin Investig Drugs. 2013 Feb;22(2):277-84.

3. Wong BS, et al. Am J Gastroenterol. 2011 Dec;106(12):2154-64.

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