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Embricitinib

Chemical Structure : Embricitinib

CAS No.: 2459377-98-9

Embricitinib (JAK1-IN-18)

Catalog No.: PC-27421Not For Human Use, Lab Use Only.

Embricitinib is a potent, selective JAK1 inhibitor with IC50 of 0.15 nM, 3.69 nM, 3.10 nM and 1.49 nM for JAK1, JAK2, JAK3 and TYK2 respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Embricitinib is a potent, selective Janus kinase (JAK) family inhibitor with IC50 of 0.15 nM, 3.69 nM, 3.10 nM and 1.49 nM for JAK1, JAK2, JAK3 and TYK2 respectively.

Physicochemical Properties

M.Wt 366.37
Formula C16H20F2N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-((3-((2,2-difluoroethyl)carbamoyl)piperidin-1-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

References

1. Patent WO2020156271 A1 2020-08-06.

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