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Emixustat

Chemical Structure : Emixustat

CAS No.: 1141777-14-1

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Emixustat (ACU-4429, ACU4429)

Catalog No.: PC-45684Not For Human Use, Lab Use Only.

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $348 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
Emixustat (ACU-4429 reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50 = 0.18 mg/kg).

Physicochemical Properties

M.Wt 263.3752
Formula C16H25NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 43 mg/mL
Chemical Name/SMILES

Benzenemethanol, α-(2-aminoethyl)-3-(cyclohexylmethoxy)-, (αR)-

References

1. Kiser PD, et al. Nat Chem Biol. 2015 Jun;11(6):409-15.

2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940.

3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.

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