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Chemical Structure : Empesertib
CAS No.: 1443763-60-7
Catalog No.: PC-43261Not For Human Use, Lab Use Only.
Empesertib (BAY-1161909, BAY1161909) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.34 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Empesertib (BAY-1161909, BAY1161909) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.34 nM.
BAY1161909 inhibits only JNK2 and JNK3 more than 50% at 1 uM in Millipore panel (230 kinases).
BAY1161909 abrogates nocodazole-induced metaphase arrest in HeLa cells with IC50 of 56 nM, inhibits the proliferation of a panel tumor cell lines covering various cancer with mean IC50 of 160 nM.
BAY1161909 enhances the efficacy of antimitotic cancer drugs and shows potentially overcome resistance in vivo.
| M.Wt | 559.6113 | |
| Formula | C29H26FN5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
Benzeneacetamide, 4-fluoro-N-[4-[2-[[2-methoxy-4-(methylsulfonyl)phenyl]amino][1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]-α-methyl-, (αR)- |
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1. Wengner AM, et al. Mol Cancer Ther. 2016 Apr;15(4):583-92.
2. Uitdehaag JCM, et al. J Mol Biol. 2017 Jul 7;429(14):2211-2230.
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