Catalog No.: PC-45529Not For Human Use, Lab Use Only.
Enasidenib (AG-221, CC-90007) is an orally available, selective, potent inhibitor of mutant IDH2 with IC50s of 100-400 nM for IDH2R140Q homodimer, IDH2R172K homodimer and IDH2WT/R140Q, IDH2WT/R172K.
Enasidenib (AG-221, CC-90007) is an orally available, selective, potent inhibitor of mutant IDH2 with IC50s of 100-400 nM for IDH2R140Q homodimer, IDH2R172K homodimer and IDH2WT/R140Q, IDH2WT/R172K.
Enasidenib (AG-221, CC-90007) is less potent for IDH2WT homodimer and IDH1WT homodimer.
Enasidenib (AG-221, CC-90007) suppresses 2HG production and induces cellular differentiation in primary human IDH2 mutation-positive AML cells ex vivo and in xenograft mouse models.
