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Endosidin 9

Chemical Structure : Endosidin 9

CAS No.: 693806-53-0

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Endosidin 9 (Clathrin inhibitor ES9)

Catalog No.: PC-72982Not For Human Use, Lab Use Only.

Endosidin 9 (ES9) is a novel mitochondrial uncoupler, and a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems, strongly reduces FM4-64 uptake in Arabidopsis root cells with IC50 of 5 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Endosidin 9 (ES9) is a novel mitochondrial uncoupler, and a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems, strongly reduces FM4-64 uptake in Arabidopsis root cells with IC50 of 5 uM.
    Endosidin 9 (ES9) inhibits CME dynamics and organelle movement in the cytoplasm.
    Endosidin9 (ES9) inhibits clathrin-mediated endocytosis largely through cytoplasmic acidification.

    Physicochemical Properties

    M.Wt 363.2
    Formula C10H7BrN2O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide

    References

    1. Dejonghe W, et al. Nat Chem Biol. 2019 Jun;15(6):641-649.

    2. Dejonghe W, et al. Nat Commun. 2016 Jun 8;7:11710.

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