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Chemical Structure : Endosomal trafficking inhibitor EGA
CAS No.: 415687-81-9
Catalog No.: PC-70343Not For Human Use, Lab Use Only.
EGA is a potent anthrax lethal toxin entry inhibitor with IC50 of 1.7 uM, inhibits endosomal trafficking pathways exploited by multiple toxins and viruses.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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EGA is a potent anthrax lethal toxin entry inhibitor with IC50 of 1.7 uM, inhibits endosomal trafficking pathways exploited by multiple toxins and viruses.
EGA also delays lysosomal targeting and degradation of the EGF receptor, does not neutralize acidic organelles.
EGA is a powerful tool for the study of membrane trafficking and represents a class of host-targeted compounds for therapeutic development to treat infectious disease.
| M.Wt | 346.22 | |
| Formula | C16H16BrN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone |
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1. Gillespie EJ, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12.
2. Jung ME, et al. ACS Med Chem Lett. 2014 Jan 21;5(4):363-7.
3. Slater LH, et al. Trends Microbiol. 2014 Feb;22(2):53-5.
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