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Chemical Structure : Epalrestat
CAS No.: 82159-09-9
Catalog No.: PC-45922Not For Human Use, Lab Use Only.
Epalrestat (ONO-2235) is a noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $78 | In stock | |
| 50 mg | $118 | In stock | |
| 100 mg | $178 | In stock | |
| 250 mg | Get quote |
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Epalrestat (ONO-2235) is a noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively.
Epalrestat (ONO-2235) is used for the treatment of diabetic neuropathy.
| M.Wt | 319.3986 | |
| Formula | C15H13NO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 3.1 mg/mL |
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| Chemical Name/SMILES |
3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)- |
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1. Yasuda H, et al. Diabetes. 1989 Jul;38(7):832-8.
2. Terashima H, et al. J Pharmacol Exp Ther. 1984 Apr;229(1):226-30.
3. Hotta N, et al. Diabet Med. 2012 Dec;29(12):1529-33.
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