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Epalrestat

Chemical Structure : Epalrestat

CAS No.: 82159-09-9

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Epalrestat (ONO-2235, ONO2235)

Catalog No.: PC-45922Not For Human Use, Lab Use Only.

Epalrestat (ONO-2235) is a noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively.

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100 mg $178 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Epalrestat (ONO-2235) is a noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively.
Epalrestat (ONO-2235) is used for the treatment of diabetic neuropathy.

Physicochemical Properties

M.Wt 319.3986
Formula C15H13NO3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 3.1 mg/mL
Chemical Name/SMILES

3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-

References

1. Yasuda H, et al. Diabetes. 1989 Jul;38(7):832-8.

2. Terashima H, et al. J Pharmacol Exp Ther. 1984 Apr;229(1):226-30.

3. Hotta N, et al. Diabet Med. 2012 Dec;29(12):1529-33.

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