Catalog No.: PC-45827Not For Human Use, Lab Use Only.
Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM.
Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) that inhibits fatty acid β-oxidation in rat liver with IC50 of 5-20 nM.
Etomoxir affects ketogenesis, cholesterol synthesis, and gluconeogenesis both in vitro and in vivo.
Etomoxir decreases viability in LNCaP, VCaP, and patient-derived benign and prostate cancer cells, associated with decreased AR expression, decreased mTOR signaling, and increased caspase-3 activation.
Etomoxir decreases xenograft growth in mice.
