F114 | Aurora/LIMK inhibitor | Probechem Biochemicals

Chemical Structure : F114

F114 (Aurora/LIMK inhibitor)

Catalog No.: PC-73347Not For Human Use, Lab Use Only.

F114 is a novel, first-in-class, dual aurora and lim kinase (LIMK) inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1, respectively, F114 inhibits GBM proliferation and invasion.

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Biological Activity

F114 is a novel, first-in-class, dual Aurora and lim kinase (LIMK) inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1, respectively, F114 inhibits GBM proliferation and invasion.

Physicochemical Properties

M.Wt	312.377
Formula	C16H20N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-isopropyl-2-((1-isopropyl-1H-pyrazol-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

References

1. Matthew J Rybin, et al. Bioorg Med Chem Lett. 2022 Apr 1;61:128614.

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