F759 | Cyclophilin inhibitor | Probechem Biochemicals

Chemical Structure : F759

F759 (F 759)

Catalog No.: PC-20736Not For Human Use, Lab Use Only.

F759 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.

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Biological Activity

F759 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.
F759 has potent and specific inhibitory activity against CypA, CypB, and CypD.
F759 prevents mPTP opening in mitochondria from primary human and mouse hepatocytes and protected mice from liver ischemia-reperfusion injury upon binding catalytic and gatekeeper pockets of CypD.

Physicochemical Properties

M.Wt	474.62
Formula	C27H30N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC(C1=CC=CC=C1)C(N2C(C3=CC=CC=C3SC)CCC2)=O)NCC4=CC=C(N)C=C4

References

1. Jens Van Bael, et al. Int J Mol Sci. 2023 Apr 12;24(8):7163.

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F759 (F 759)

Biological Activity

Physicochemical Properties

References

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