F83236 | Cyclophilin inhibitor | Probechem Biochemicals

Chemical Structure : F83236

F83236 (F 83236)

Catalog No.: PC-20735Not For Human Use, Lab Use Only.

F83236 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.

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Biological Activity

F83236 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.
F83236 has potent and specific inhibitory activity against CypA, CypB, and CypD.
F83236 prevents mPTP opening in mitochondria from primary human and mouse hepatocytes and protected mice from liver ischemia-reperfusion injury upon binding catalytic and gatekeeper pockets of CypD.

Physicochemical Properties

M.Wt	633.61
Formula	C32H33BrN4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NCC1=CC2=C(NCCC2)C=C1)NC(C3=CC(Br)=CC=C3OC)C(N4C(C5=C6C(C=CS6)=CC=C5)CCC4)=O

References

1. Jens Van Bael, et al. Int J Mol Sci. 2023 Apr 12;24(8):7163.

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F83236 (F 83236)

Biological Activity

Physicochemical Properties

References

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