Chemical Structure : FAH65
CAS No.:
2086224-17-9
FAH65
Catalog No.: PC-24656Not For Human Use, Lab Use Only.
FAH65 is a potent, APP-selective BACE1 inhibitor with IC50 of 0.01 uM in in cell-free assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FAH65 is a potent, APP-selective BACE1 inhibitor with IC50 of 0.01 uM in in cell-free assays.
FAH65 displays selectivity for inhibition of APP cleavage with little activity against other BACE1 substrates neuregulin 1 (NRG1) or p-selectin glycoprotein ligand-1 (PSGL1).
FAH65 inhibits sAPPβ and Aβ1-42 production in APP-expressing cells in vitro.
FAH65 reduces BACE1 cleavage products soluble APPβ (sAPPβ) and the β C-terminal fragment (βCTF), as well as amyloid-β (Aβ) 1-40 and 1-42 in vivo in an animal model of AD.
FAH65 improved the discrimination score in the Novel Object Recognition (NOR) memory testing paradigm in murine model of AD.
Physicochemical Properties
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M.Wt
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423.42
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Formula
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C22H19F2N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-amino-5-(4-(difluoromethoxy)-3-methylphenyl)-3-methyl-5-(3-(pyrimidin-5-yl)phenyl)-3,5-dihydro-4H-imidazol-4-one
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References
1. Campagna J, et al. Neurotherapeutics. 2025 May 20:e00610.
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