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FAUC 1036

Chemical Structure : FAUC 1036

CAS No.: 1869983-83-4

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FAUC 1036 (FAUC1036;FAUC-1036)

Catalog No.: PC-61170Not For Human Use, Lab Use Only.

FAUC 1036 is a potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FAUC 1036 is a potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.

    Physicochemical Properties

    M.Wt 744.933
    Formula C45H52N4O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    tert-Butyl {(S)-1-[(2,2-diphenylethyl)amino]-1-oxo-6-[(S)-2-(4-oxo-4-phenylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido]hexan-2-yl}carbamate

    References

    1. Milanos L, et al. J Med Chem. 2016 Mar 10;59(5):2222-43.

    2. Milanos L, et al. Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15277-15281.

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