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FC131

Chemical Structure : FC131

CAS No.: 606968-52-9

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FC131 (FC 131;cyclo(-D-Tyr-Arg-Arg-Nal-Gly-))

Catalog No.: PC-61965Not For Human Use, Lab Use Only.

FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21 nM..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21 nM.

Physicochemical Properties

M.Wt 729.84
Formula C36H47N11O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,1'-(((2S,5S,8S,14R)-14-(4-hydroxybenzyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecane-2,5-diyl)bis(propane-3,1-diyl))diguanidine

References

1. Tamamura H, et al. J Med Chem. 2005 Jan 27;48(2):380-91.

2. Thiele S, et al. Br J Pharmacol. 2014 Dec;171(23):5313-29.

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