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FD-44

Chemical Structure : FD-44

CAS No.: 68207-21-6

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FD-44 (FD44;NCS-1-Ric8a inhibitor FD44)

Catalog No.: PC-70286Not For Human Use, Lab Use Only.

FD-44 (FD44, NCS-1-Ric8a inhibitor FD44) is a potent inhibitor of the NCS-1/Ric8a interaction, interferes with NCS-1/Ric8a binding, and restores normal synapse number and associative learning in a Drosophila FXS model.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FD-44 (FD44, NCS-1-Ric8a inhibitor FD44) is a potent inhibitor of the NCS-1/Ric8a interaction, interferes with NCS-1/Ric8a binding, and restores normal synapse number and associative learning in a Drosophila FXS model.

    Physicochemical Properties

    M.Wt 339.457
    Formula C19H21N3OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(10H-phenothiazin-10-yl)-2-(piperidin-1-yl)acetamide

    References

    1. Mansilla A, et al. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E999-E1008.

    2. Roca C, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00088.

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