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FG-0041

Chemical Structure : FG-0041

CAS No.: 53946-49-9

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FG-0041 (FG0041)

Catalog No.: PC-21729Not For Human Use, Lab Use Only.

FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.
FG-0041 in low micromolar concentrations led to the dose-dependent accumulation of HIF1α in a variety of mammalian cells, accumulated transcriptionally active HIF.
FG-0041 also inhibits asparagine hydroxylation. FG-0041 was shown earlier to preserve left ventricular function in a rodent model of myocardial infarction.

Physicochemical Properties

M.Wt 240.22
Formula C13H8N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid

References

1. Mircea Ivan, et al. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13459-64.

2. Nwogu J I, et al. Circulation. 2001;104:2216–2221.

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