Catalog No.: PC-21729Not For Human Use, Lab Use Only.
FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.
FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.
FG-0041 in low micromolar concentrations led to the dose-dependent accumulation of HIF1α in a variety of mammalian cells, accumulated transcriptionally active HIF.
FG-0041 also inhibits asparagine hydroxylation. FG-0041 was shown earlier to preserve left ventricular function in a rodent model of myocardial infarction.
