Catalog No.: PC-24553Not For Human Use, Lab Use Only.
FGH10019 is a specific small molecule inhibitor of sterol regulatory element-binding protein (SREBP) with IC50 of 0.7 uM in SREBP-responsive reporter gene assays.
FGH10019 is a specific small molecule inhibitor of sterol regulatory element-binding protein (SREBP) with IC50 of 0.7 uM in SREBP-responsive reporter gene assays. FGH10019 is comparable to the potency of an endogenous inhibitor, 25- hydroxycholesterol, which has an IC50 value of 0.3 uM. FGH10019 decreases the percentage of the mature form of SREBP-2 at lower concentrations (IC50=1 uM) than treatment with Fatostatin (Cat# PC-22262). FGH10019 (1-20 uM) decreases the expression of SREBP-responsive genes in DU145 cells. FGH10019 is orally available in mice.
