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FGI-103

Chemical Structure : FGI-103

CAS No.: 907169-69-1

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FGI-103 (FGI103)

Catalog No.: PC-62051Not For Human Use, Lab Use Only.

FGI-103 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FGI-103 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67); protects mice against a lethal challenge with a mouse-adapted strain of either ZEBOV or MARV-Ravn as a single intraperitoneal dose of 10 mg/kg; reduces viremia and the viral burden in kidney, liver, and spleen tissues in a murine model of ZEBOV infection.

Physicochemical Properties

M.Wt 344.369
Formula C19H16N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[(E)-2-(5-Carbamimidoyl-1-benzofuran-2-yl)vinyl]-1H-benzimidazol-6-carboximidamid

References

1. Warren TK, et al. Antimicrob Agents Chemother. 2010 May;54(5):2152-9.

2. Haque A, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):5892-902.

3. De Clercq E. Med Res Rev. 2013 Nov;33(6):1249-77.

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