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Chemical Structure : FGI-104
Catalog No.: PC-62052Not For Human Use, Lab Use Only.
FGI-104 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67).
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FGI-104 is a small-molecule inhibitor of filovirus that exhibits potent antiviral activity against of EBOV (EC90=330 nM, ZEBOV) and MARV (EC50=2.5 uM, MARV-Ci67); protects mice against a lethal challenge with a mouse-adapted strain of either ZEBOV or MARV-Ravn as a single intraperitoneal dose of 10 mg/kg; reduces viremia and the viral burden in kidney, liver, and spleen tissues in a murine model of ZEBOV infection.
| M.Wt | 492.016 | |
| Formula | C28H30ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Warren TK, et al. Antimicrob Agents Chemother. 2010 May;54(5):2152-9.
2. Haque A, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):5892-902.
3. De Clercq E. Med Res Rev. 2013 Nov;33(6):1249-77.
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