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FGI-106

Chemical Structure : FGI-106

CAS No.: 501081-38-5

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FGI-106 (FGI106)

Catalog No.: PC-62053Not For Human Use, Lab Use Only.

FGI-106 is a broad-spectrum inhibitor of multiple blood-borne viruses (HCV, HBV, HIV) as well as emerging biothreats (Ebola, VEE, Cowpox, PRRSV infection) with EC50 of 0.2-10 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FGI-106 is a broad-spectrum inhibitor of multiple blood-borne viruses (HCV, HBV, HIV) as well as emerging biothreats (Ebola, VEE, Cowpox, PRRSV infection) with EC50 of 0.2-10 uM; inhibits the interaction of TSG101 with its cognate viral ligands; displays an ability to prevent lethality from Ebola in vivo; well-tolerated and orally bioavailable.

Physicochemical Properties

M.Wt 458.654
Formula C28H38N6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Quino[8,7-h]quinoline-1,7-diamine, N,N'-bis[3-(dimethylamino)propyl]-3,8-dimethyl- (9CI)

References

1. Kinch MS, et al. Am J Transl Res. 2009 Jan 5;1(1):87-98.

2. De Clercq E. Med Res Rev. 2013 Nov;33(6):1249-77.

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