FIIN-4

Chemical Structure : FIIN-4

Catalog No.: PC-28540Not For Human Use, Lab Use Only.

FIIN-4 is a first-in-class, orally active and covalent FGFR inhibitor with IC50 of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

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Biological Activity

FIIN-4 is a first-in-class, orally active and covalent FGFR inhibitor with IC50 of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

Physicochemical Properties

M.Wt	634.74
Formula	C35H38N8O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((3-(3,5-Dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide

References

1. Wells S Brown, et al. Mol Cancer Ther. 2016 Sep;15(9):2096-106.

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FIIN-4

Biological Activity

Physicochemical Properties

References

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