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Chemical Structure : FK614
Catalog No.: PC-72023Not For Human Use, Lab Use Only.
FK614 (FK 614) is a PPARγ agonist.
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FK614 (FK 614) is a PPARγ agonist.
FK614 shows a potent attenuating effect on hypertriglyceridemia in db/db mice.
In C57BL/6J-ob/ob mice (ob/ob mice), ED50 value of FK614 for hypoinsulinemic effect was 1.3 mg/kg.
FK614 improves peripheral glucose utilization because of an improvement in peripheral insulin sensitivity and a decrease in insulin clearance, but impairs hepatic insulin action in alloxan-induced diabetic dogs.
| M.Wt | 468.393 | |
| Formula | C21H23Cl2N3O3S | |
| Appearance | Solid | |
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1. Minoura H, et al. Eur J Pharmacol. 2004 Jun 28;494(2-3):273-81.
2. Minoura H, et al. Eur J Pharmacol. 2005 Sep 5;519(1-2):182-90.
3. Fujimura T, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):863-71.
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