FK614 | PPARγ agonist | Probechem Biochemicals

Chemical Structure : FK614

FK614 (FK 614)

Catalog No.: PC-72023Not For Human Use, Lab Use Only.

FK614 (FK 614) is a non-thiazolidinedione (TZD), orally active PPARγ agonist.

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Biological Activity

FK614 (FK 614) is a non-thiazolidinedione (TZD), orally active PPARγ agonist.
FK614 shows a potent attenuating effect on hypertriglyceridemia in db/db mice.
In C57BL/6J-ob/ob mice (ob/ob mice), ED50 value of FK614 for hypoinsulinemic effect was 1.3 mg/kg.
FK614 improves peripheral glucose utilization because of an improvement in peripheral insulin sensitivity and a decrease in insulin clearance, but impairs hepatic insulin action in alloxan-induced diabetic dogs.

Physicochemical Properties

M.Wt	468.393
Formula	C21H23Cl2N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2,4-dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide

References

1. Minoura H, et al. Eur J Pharmacol. 2004 Jun 28;494(2-3):273-81.

2. Minoura H, et al. Eur J Pharmacol. 2005 Sep 5;519(1-2):182-90.

3. Fujimura T, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):863-71.

FK614 (FK 614)

Biological Activity

Physicochemical Properties

References

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