Catalog No.: PC-72870Not For Human Use, Lab Use Only.
FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.
FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.
FL-18 showed better inhibition potency than NMS-873, a well-known p97 inhibitor.
FL-18 covalently modified C522 residue in p97 and showed potent enzymatic inhibition.
FL-18 showed potent inhibition towards U87MG glioma cancer cells (IC50=31 nM).
FL-18 inhibited the p97 activity and induced aggregation of ubiquitinated proteins in U87MG cells.
