| Cat. No. |
Product Name |
Information |
| PC-22572 |
UP109
VCP activator
|
UP109 is a small molecule activator of VCP ATPase activity with EC50 of 24.7 uM, Emax of 197%, activates VCP primarily by increasing D2 ATPase activity. |
| PC-21286 |
VCP Activator 1
VCP/p97 activator
|
VCP Activator 1 (VA1) is a small molecule allosteric activator of valosin-containing protein (VCP)/p97, dose-dependently stimulates VCP ATPase activity up to 3-fold (EC50= 4 uM). |
| PC-49108 |
NW1030
p97 modulator
|
NW1030 is a small molecule that target the regulatory domain of VCP/p97, increases the degradation of a p97-dependent reporter, does not affect the main catalytic domain of p97. |
| PC-49107 |
NW1028
p97 modulator
|
NW1028 is a small molecule that target the regulatory domain of VCP/p97, inhibits the degradation of a p97-dependent reporter, does not affect the main catalytic domain of p97. |
| PC-38720 |
OSSL_325096
p97/VCP inhibitor
|
OSSL_325096 is a novel potent small mlolecule p97/VCP inhibitor, suppresses cell proliferation and induces ER stress and apoptotic cell death in MM cell lines (IC50=0.1-0.5 uM). |
| PC-38468 |
NMS-873
p97/VCP inhibitor
|
NMS-873 (NMS873) is a potent, specific, cell-permeable, non-ATP competitive, allosteric inhibitor of VCP/p97 ATPase with IC50 of 30 nM. |
| PC-72870 |
FL-18
p97 inhibitor
|
FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity. |
| PC-72409 |
CB5339
VCP/p97 inhibitor
|
CB5339 (CB-5339) is a second-generation, potent, selective, ATP-competitive, and oral inhibitor of valosin-containing protein (VCP/p97) with IC50 of 9 nM. |
| PC-36136 |
LC-1028
p97/VCP inhibitor
|
LC-1028 (LC1028) is a novel potent selective, covalent and irreversible inhibitor of p97 (valosin-containing protein), remains essentially irreversible ac tivity against p97 mutant C522A.. |
| PC-35960 |
NPD8733
p97 inhibitor
|
NPD8733 (NPD-8733) is a small-molecule ligand of valosin-containing protein (VCP)/p97, binds to the D1 domain of VCP/p97. |
| PC-63243 |
UPCDC30245
p97/VCP inhibitor
|
UPCDC-30245 is a potent, cell penetrant allosteric p97/VCP inhibitor with IC50 of 300 nM (WT p97), also potently inhibits CB-5083 resistant p97 D649A/T688A mutant. |
| PC-43263 |
CB-5083
p97 inhibitor
|
CB-5083 is a potent, selective, orally bioavailable inhibitor of p97/VCP AAA ATPase with IC50 of 11 nM, specifically targets D2 ATPase site of p97, shows 9.6, 128 and 158-fold less affinity for DNA-PK, mTOR and PIK3C3. |
