GND-135 | VCP/p97 inhibitor | Probechem Biochemicals

Chemical Structure : GND-135

GND-135 (GND135)

Catalog No.: PC-27077Not For Human Use, Lab Use Only.

GND-135 is a potent, cell-permeable, and orally bioavailable inhibitor of VCP/p97 AAA ATPase with IC50 of <10 nM.

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Biological Activity

GND-135 is a potent, cell-permeable, and orally bioavailable inhibitor of VCP/p97 AAA ATPase with IC50 of <10 nM.
GND-135 eliminates PDE6 cross-reactivity while maintaining VCP/p97 potency.
GND-135 has comparable in vivo efficacy compared to CB-5083.

Physicochemical Properties

M.Wt	536.64
Formula	C31H32N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(benzylamino)-2-methyl-1-(2-morpholino-2-oxoethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-2-methyl-1H-indole-4-carboxamide

References

1. Crawford J, et al. IUCrJ. 2026 Jul 1. doi: 10.1107/S2052252526004604.

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GND-135 (GND135)

Biological Activity

Physicochemical Properties

References

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