Chemical Structure : VPS4 inhibitor 4-107
CAS No.:
1346527-45-4
VPS4 inhibitor 4-107
Catalog No.: PC-24320Not For Human Use, Lab Use Only.
VPS4 inhibitor 4-107 is a DBeQ derivative and vacuolar protein sorting 4 (VPS4) AAA-ATPase inhibitor (IC50=3.7 uM, VPS4B), inhibits VPS4 ATPase activity, induces CASP8-mediated apoptosis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VPS4 inhibitor 4-107 is a DBeQ derivative and vacuolar protein sorting 4 (VPS4) AAA-ATPase inhibitor (IC50=3.7 uM, VPS4B), inhibits VPS4 ATPase activity, induces CASP8-mediated apoptosis.
VPS4 inhibitor 4-107 is modestly selective for VPS4B in vitro over VCP (IC50=8.6 uM).
VPS4 inhibitor 4-107 4-107 (1 μM) does not induce ER stress or the accumulation of polyubiquitinated proteins, unlike CB-5083.
VPS4 inhibitor 4-107 exhibits improved cellular potency and selectivity for VPS4 compared with DBeQ.
4-107 induces ESCRT accumulation on LC3-positive autophagosomal membranes.
4-107 exhibits lysosomotropic properties and disrupts endolysosomal membrane integrity.
4-107 induces CASP8-mediated VPS4-sensitive cell death
4-107 (5 mg/kg/day, i.p.) suppresses tumor growth in syngeneic mouse model of neuroblastoma, without causing severe toxicity in mice.
Physicochemical Properties
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M.Wt
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370.46
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Formula
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C23H22N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N2,N4-dibenzyl-8-methoxyquinazoline-2,4-diamine
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References
1. Fundora KA, et al. J Pharmacol Exp Ther. 2025 Feb 28;392(4):103524.
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