NMS-859 | VCP/p97 inhibitor | Probechem Biochemicals

Chemical Structure : NMS-859

CAS No.: 1449236-96-7

NMS-859 (NMS859)

Catalog No.: PC-26296Not For Human Use, Lab Use Only.

NMS-859 is a covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 0.37 uM, covalently modifies VCP on the active site Cys522 and blocks ATP binding.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$428	In stock
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Biological Activity

NMS-859 is a covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 0.37 uM, covalently modifies VCP on the active site Cys522 and blocks ATP binding.

Physicochemical Properties

M.Wt	349.79
Formula	C15H12ClN3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide

References

1. Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56.

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NMS-859 (NMS859)

Biological Activity

Physicochemical Properties

References

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