| Cat. No. |
Product Name |
Information |
| PC-43263 |
CB-5083
p97 inhibitor
|
CB-5083 is a potent, selective, orally bioavailable inhibitor of p97/VCP AAA ATPase with IC50 of 11 nM, specifically targets D2 ATPase site of p97, shows 9.6, 128 and 158-fold less affinity for DNA-PK, mTOR and PIK3C3. |
| PC-62542 |
MSC1094308
p97/VPS4B inhibitor
|
MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively. |
| PC-45718 |
ML-241
p97 inhibitor
|
ML241 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM). |
| PC-45719 |
ML-241 hydrochloride
p97 inhibitor
|
ML241 hydrochloride is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM). |
| PC-45717 |
ML240
p97 inhibitor
|
ML240 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM). |
| PC-26297 |
p97 inhibitor PPA
VCP/p97 inhibitor
|
p97 inhibitor PPA (ACJI-99C) is a selective, covalent p97/VCP ATPase inhibitor with IC50 of 0.6 uM in in vitro ATPase activity assay, with no activity against yeast Cdc48, and N-ethylmaleimide sensitive factor (NSF). |
| PC-26296 |
NMS-859
VCP/p97 inhibitor
|
NMS-859 is a covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 0.37 uM, covalently modifies VCP on the active site Cys522 and blocks ATP binding. |
| PC-26295 |
UTE-156
VCP/p97 inhibitor
|
UTE-156 is a potent, covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 10 nM, modifies Cys522 within the D2 ATPase domain of VCP. |
| PC-25309 |
Eeyarestatin ES24
p97/VCP inhibitor, Sec61 inhibitor
|
Eeyarestatin ES24 is a specific inhibitor of p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), induces Ca2+-dependent cell death, targets the Sec61 complexes. |
| PC-25308 |
Eeyarestatin I
VCP inhibitor, ERAD inhibitor, Sec61 inhibitor
|
Eeyarestatin I (Eeyarestatin 1, ESI, ES1) is a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination, inhibits Sec61 translocon. |
| PC-24319 |
DBeQ
p97/VCP inhibitor, VPS4 inhibitor
|
DBeQ is a selective, potent, reversible, and ATP-competitive AAA ATPase p97/VCP inhibitor with IC50 of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A) respectively, also inhibits VPS4 with IC50 of 11.5 uM. |
| PC-22873 |
Thonzonium bromide
p97-Npl4 inhibitor
|
Thonzonium bromide is an antibacterial agent, inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo, also is a ATPase p97-Npl4 interaction, boosts antitumor immunity without affecting peripheral Treg cell homeostasis. |
