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ML-240

Chemical Structure : ML-240

CAS No.: 1346527-98-7

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ML-240 (ML 240;ML-240)

Catalog No.: PC-45717Not For Human Use, Lab Use Only.

ML240 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).

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100 mg $398 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML240 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).
ML240 blocks degradation of p97-dependent proteasome substrate with an IC50 of 0.9 uM.
ML240 induces caspases 3 and 7 and potently blocked proliferation in HCT15 and SW403 cells.

Physicochemical Properties

M.Wt 396.4445
Formula C23H20N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 16.5 mg/mL
Chemical Name/SMILES

4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-

References

1. Chou TF, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312.

3. Bastola P, et al. Mol Oncol. 2016 Dec;10(10):1559-1574.

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