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Chemical Structure : MSC 1094308
CAS No.: 2219320-08-6
Catalog No.: PC-62542Not For Human Use, Lab Use Only.
MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.
MSC1094308 binds to drugable hotspot of p97, thereby inhibiting the D2 ATPase activity.
MSC1094308 is active in cells, and specifically inhibits p97 but not the proteasome.
| M.Wt | 462.56 | |
| Formula | C29H29F3N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-4,4-bis(4-fluorophenyl)butan-1-amine |
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1. Pöhler R, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.
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