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MSC1094308

Chemical Structure : MSC1094308

CAS No.: 2219320-08-6

MSC1094308 (MSC-1094308)

Catalog No.: PC-62542Not For Human Use, Lab Use Only.

MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.

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Purity & Documentation Purity: 98.49% (HPLC) Select Batch:

Biological Activity

MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.
MSC1094308 binds to drugable hotspot of p97, thereby inhibiting the D2 ATPase activity.
MSC1094308 is active in cells, and specifically inhibits p97 but not the proteasome.

Physicochemical Properties

M.Wt 462.56
Formula C29H29F3N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-4,4-bis(4-fluorophenyl)butan-1-amine

References

1. Pöhler R, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.

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