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ML-241

Chemical Structure : ML-241

CAS No.: 1346528-06-0

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ML-241 (ML 241;ML241)

Catalog No.: PC-45718Not For Human Use, Lab Use Only.

ML241 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML241 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).
ML241 blocks degradation of p97-dependent proteasome substrate with an IC50 of 3.5 uM.
ML241 induces caspases 3 and 7 and potently blocks proliferation in HCT15 and SW403 cells.

Physicochemical Properties

M.Wt 372.46
Formula C23H24N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

References

1. Chou TF, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312.

3. Fang CJ, et al. ChemMedChem. 2015 Jan;10(1):52-6.

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