Chemical Structure : ML-241 hydrochloride
CAS No.: 2070015-13-1
Catalog No.: PC-45719Not For Human Use, Lab Use Only.
ML241 hydrochloride is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).
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ML241 hydrochloride is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).
ML241 blocks degradation of p97-dependent proteasome substrate with an IC50 of 3.5 uM.
ML241 induces caspases 3 and 7 and potently blocks proliferation in HCT15 and SW403 cells.
M.Wt | 408.9238 | |
Formula | C23H25ClN4O | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 34 mg/mL |
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Chemical Name/SMILES |
4-Quinazolinamine, 2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-N-(phenylmethyl)-,hydrochloride |
1. Chou TF, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312.
3. Fang CJ, et al. ChemMedChem. 2015 Jan;10(1):52-6.
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