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UP109

Chemical Structure : UP109

CAS No.: 781627-48-3

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UP109 (UP-109, UP 109)

Catalog No.: PC-22572Not For Human Use, Lab Use Only.

UP109 is a small molecule activator of VCP ATPase activity with EC50 of 24.7 uM, Emax of 197%, activates VCP primarily by increasing D2 ATPase activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UP109 is a small molecule activator of VCP ATPase activity with EC50 of 24.7 uM, Emax of 197%, activates VCP primarily by increasing D2 ATPase activity.
UP109 has at least some specificity for VCP over other AAA+ ATPases.
UP109 likely binds in the D2 ATPase domain of VCP.
UP109 (5 uM) effectively enhances clearance of TDP-4FL aggregates in cells expressing GFP-TDP-4FL.
UP109 is also effective in assisting clearance of TDP-4FL aggregates in iPSC-derived neurons.

Physicochemical Properties

M.Wt 454.47
Formula C17H18N4O7S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-(2-methoxyethyl)ureido)-2-oxoethyl 2-((4-methylthiazol-2-yl)thio)-5-nitrobenzoate

References

1. Phan JM, et al. J Clin Invest. 2024 May 23:e169039.

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