Chemical Structure : FLIPinBγ
CAS No.:
2408994-99-8
FLIPinBγ
Catalog No.: PC-23805Not For Human Use, Lab Use Only.
FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.
FLIPinBγ does not act via modulating the protein level of c-FLIPL.
FLIPinBγ acts via enhancement of caspase-8 activity at the DISC.
c-FLIPL, the long isoform of c-FLIP, is a DED-containing protein and a key regulator of the extrinsic apoptosis pathway. DISC comprises DR, FADD, procaspase-8/10 and c-FLIPL/S/R proteins, DISC serves as a platform for procaspase-8 activation, which takes place upon its oligomerization in the death effector domain (DED)-filaments, initiating the apoptotic destruction of the cell.
Physicochemical Properties
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M.Wt
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516.57
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Formula
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C27H24N4O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-(pyridin-4-yl)benzamido)ethyl 3-(N-(pyridin-3-ylmethyl)sulfamoyl)benzoate
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References
1. Hillert LK, et al. Cell Death Differ. 2020 Jul;27(7):2117-2130.
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