Chemical Structure : FOXA1/2 inhibitor compound T
CAS No.:
886119-85-3
FOXA1/2 inhibitor compound T
Catalog No.: PC-25581Not For Human Use, Lab Use Only.
FOXA1/2 inhibitor compound T is a small molecule inhibitor of collaboration between FOXA1 and FOXA2, disrupt the FOXA1/2 function, binds to forkhead domain of FOXA1 of SPR KD of 100 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FOXA1/2 inhibitor compound T is a small molecule inhibitor of collaboration between FOXA1 and FOXA2, disrupts the FOXA1/2 function, binds to forkhead domain of FOXA1 of SPR KD of 100 uM.
Compound T also reduced the luciferase reporter assay driven by the homolog FOXA3.
Compound T also disabled the FOXA1 and FOXA2 forkhead domain from binding to an immobilized double-strand DNA oligonucleotide by biolayer interferometry (BLI).
Compound T disrupted the binding of all three nucleotide sequences (i.e., C, PAL, and 2C) to either the forkhead domains of FOXA1, FOXA2, and FOXA1/FOXA2.
Compound T reduced FOXA1 chromatin binding in LNCaP cells, reduced FOXA1 and FOXA2 chromatin occupancy in PC3 cells.
Compound T selectively suppressed the clonogenic growth of cell lines expressing FOXA1 or FOXA1/2.
Physicochemical Properties
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M.Wt
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360.21
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Formula
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C14H11Cl2NO4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((4,5-dichloro-2-methylphenyl)sulfonamido)benzoic acid
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References
1. Formaggio N, et al. Cell Rep. 2025 Sep 26;44(10):116324.
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