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FOXM1 inhibitor RCM-1

Chemical Structure : FOXM1 inhibitor RCM-1

CAS No.: 339163-65-4

FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1)

Catalog No.: PC-72976Not For Human Use, Lab Use Only.

FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1) is a small molecule potent inhibitor of FOXM1 transcription factor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1) is a small molecule potent inhibitor of FOXM1 transcription factor.
RCM-1 inhibited the nuclear localization of FOXM1 protein, increased its ubiquitination and caused degradation of FOXM1 in proteasome.
RCM-1 reduced airway resistance, increased lung compliance, and decreased proinflammatory cytokine production in mice exposed to the house dust mite and interleukin-13 (IL-13), which triggers goblet cell metaplasia.
RCM-1 reduced the formation and growth of tumor cell colonies in the colony formation assay.
In animal models, RCM-1 treatment inhibited growth of mouse rhabdomyosarcoma Rd76-9, melanoma B16-F10, and human H2122 lung adenocarcinoma.
RCM-1 decreased FOXM1 protein in the tumors, reduced tumor cell proliferation, and increased tumor cell apoptosis.
RCM-1 decreased protein levels and nuclear localization of β-catenin, and inhibited protein-protein interaction between β-catenin and FOXM1 in cultured tumor cells and in vivo.

Physicochemical Properties

M.Wt 424.58
Formula C20H12N2OS4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((2-Oxo-2-(thiophen-2-yl)ethyl)thio)-4,6-di(thiophen-2-yl)nicotinonitrile

References

1. Lifeng Sun, et al. Sci Signal. 2017 Apr 18;10(475):eaai8583.

2. Samriddhi Shukla, et al. Mol Cancer Ther. 2019 Jul;18(7):1217-1229.

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