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FPTP

Chemical Structure : FPTP

CAS No.: 2096213-27-1

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FPTP

Catalog No.: PC-27196Not For Human Use, Lab Use Only.

FPTP is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 3.64 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.7 uM and 22.8 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FPTP is a pharmacological small-molecule NEK9 inhibitor with SPR KD of 3.64 uM, inhibits viability of Huh-7 and Hep3b cells with IC50 of 18.7 uM and 22.8 uM.
FPTP reduces NEK9 mRNA and protein levels in Huh-7 and Hep3b cells, NEK9 overexpression partially rescued the inhibitory effects of FPTP, but not NEK2 or NEK6.
FPTP suppresses NEK9-driven tumour growth and restore antitumour immunity in vivo, restores CD8+ T cell antitumour activity.
Combining FPTP with PD-L1 blocker CA-170 synergistically enhances antitumour immunity in HCC.

Physicochemical Properties

M.Wt 466.55
Formula C27H26N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-isopropylphenyl)-2-methyl-N-(2-(5-(pyridin-4-yl)-1,2,4-oxadiazol-3-yl)ethyl)-1H-benzo[d]imidazole-5-carboxamide

References

1. Lu G, et al. Gut. 2026 Jun 25:gutjnl-2026-338449.

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