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Chemical Structure : FR-190997
Catalog No.: PC-20273Not For Human Use, Lab Use Only.
FR-190997 (FR190997) is a potent, nonpeptide bradykinin (BK) B2 receptor agonist binding IC50 of 1.5 nM (displaced [3H]-BK binding to B2 receptors in guinea-pig ileum membranes).
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FR-190997 (FR190997) is a potent, nonpeptide bradykinin (BK) B2 receptor agonist binding IC50 of 1.5 nM (displaced [3H]-BK binding to B2 receptors in guinea-pig ileum membranes).
FR-190997 displaces [3H]-BK binding to B2 receptors in human lung fibroblast IMR-90 cell with IC50 of 0.98 nM.
FR190997 induces concentration-dependent contraction of guinea-pig ilea with a pD2 of 7.9.
FR190997 induces concentration-dependent PI hydrolysis in IMR-90 cells with a pD2 of 8.4.
FR190997 expresses longer action than bradykinin in paw edema formation and hypotensive response in vivo.
| M.Wt | 698.60 | |
| Formula | C37H33Cl2N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Asano M, et al. Br J Pharmacol. 1998 Jun;124(3):441-6.
2. Aramori I, et al. Mol Pharmacol. 1997 Jul;52(1):16-20.
3. Ueno A, et al. Immunopharmacology. 1999 Dec;45(1-3):89-93.
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